Persistent pulmonary hypertension of the newborn refractory to inhaled nitric oxide-treated with milrinone: a case report.
نویسندگان
چکیده
Current therapy of persistent pulmonary hypertension of the newborn (PPHN) consists of optimal ventilation, hemodynamic support and selective vasodilatation with inhaled nitric oxide (iNO). We present herein a case of PPHN non-responsive to iNO but treated successfully with a combination of iNO and intravenous milrinone, a phosphodiesterase III inhibitor. This case suggests that the drug may be a useful adjunctive treatment in the management of PPHN.
منابع مشابه
Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn.
BACKGROUND Many neonates with severe persistent pulmonary hypertension of the newborn (PPHN) are nonresponders to inhaled nitric oxide (iNO). Milrinone is a promising adjunctive therapy because of its pulmonary vasodilator properties and cardiotropic effects. DESIGN Case series of neonates with severe PPHN (defined as oxygenation index [OI] >20, failure of iNO therapy, and echocardiographic c...
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متن کاملPersistent pulmonary hypertension of the newborn (PPHN) treated with inhaled nitric oxide: preliminary hearing outcomes.
The hearing of 28 children, born with a diagnosis of persistent pulmonary hypertension of the newborn (PPHN) and treated with inhaled nitric oxide, was followed. The latest test for the children varied from 5 to 30 months. Of this group, three children had mild conductive hearing losses; no child had a significant sensorineural hearing loss.
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ورودعنوان ژورنال:
- The Turkish journal of pediatrics
دوره 52 1 شماره
صفحات -
تاریخ انتشار 2010